Technology Process of 4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-1H-benzimidazol-5-yl}benzonitrile
There total 5 articles about 4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-1H-benzimidazol-5-yl}benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C23H26N4O3;
With
acetic acid;
at 20 ℃;
for 96h;
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water; toluene / 5 h / 100 °C
2.1: calcium chloride; iron / water; ethanol / 5 h / 100 °C
3.1: 4-methyl-morpholine / acetonitrile / 0.58 h / 0 °C
3.2: 18 h / 20 °C
4.1: acetic acid / 96 h / 20 °C
4.2: 2 h / 20 °C
With
4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); iron; sodium carbonate; acetic acid; calcium chloride;
In
tetrahydrofuran; ethanol; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 18 h / 0 - 20 °C
2.1: 4-methyl-morpholine / acetonitrile / 0.58 h / 0 °C
2.2: 18 h / 20 °C
3.1: acetic acid / 96 h / 20 °C
3.2: 2 h / 20 °C
With
4-methyl-morpholine; sodium hydrogencarbonate; acetic acid;
In
tetrahydrofuran; water; acetonitrile;
