5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-ylmethanol

Base Information

• Chemical Name: 5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-ylmethanol
• CAS No.: 1024005-11-5
• Molecular Formula: C₁₅H₁₄F₂N₂O
• Molecular Weight: 276.286

Synonyms:5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-ylmethanol

Chemical Property of 5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-ylmethanol

Chemical Property:

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Technology Process of 5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-ylmethanol

There total 1 articles about 5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-dien-5-carboxylate (916592-23-9) → 5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2(6),3-dien-3-ylmethanol (1024005-11-5)

Guidance literature:

ethyl 3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-dien-5-carboxylate; With lithium borohydride; In tetrahydrofuran; for 2h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield: 39.0%

5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2(6),3-dien-3-ylmethanol (1024005-11-5) → 3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-dien-5-carbaldehyde (1024005-12-6)

Guidance literature:

With dipyridinium dichromate; In dichloromethane; at 20 - 35 ℃; for 3h;

Reference yield: 11.0%

5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2(6),3-dien-3-ylmethanol (1024005-11-5) + benzyl bromide (100-39-0) → 5-benzyloxymethyl-3-(2,4-difluorophenyl)-3,4-diazatricylo[5.2.1.0(2,6)]deca-2(6),4-diene (1024003-72-2)

Guidance literature:

5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-ylmethanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

benzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

upstream raw materials:

ethyl 3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-dien-5-carboxylate

Downstream raw materials:

5-benzyloxymethyl-3-(2,4-difluorophenyl)-3,4-diazatricylo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene

3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-dien-5-carbaldehyde

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