(R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

Base Information

Chemical Name:(R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane
CAS No.:1357622-30-0
Molecular Formula:C₁₆H₂₆BrN₃O₂Si
Molecular Weight:400.391
Hs Code.:

Synonyms:(R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

Suppliers and Price of (R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

There total 7 articles about (R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1357622-29-7
(S)-3-azido-2-((3-bromophenoxy)methyl)propanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1357622-30-0
(R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c1ob06632c

Reference yield:

: 1357622-26-4
(R,E)-2-(3-bromophenoxy)methyl-5-methylhex-3-enyl acetate

: 1357622-30-0
(R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

Guidance literature:: Multi-step reaction with 6 steps

1.1: ozone / methanol; dichloromethane / 0.67 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol; dichloromethane / 2.5 h / -78 - -3 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1.8 h / -30 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 20.5 h / 50 °C / Inert atmosphere

5.1: potassium hydroxide / methanol / 1 h / 0 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; sodium azide; ozone; triethylamine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06632c

Reference yield:

: 1357622-27-5
(R)-3-acetoxy-2-((3-bromophenoxy)methyl)propanol

: 1357622-30-0
(R)-1-azido-3-(tert-butyl)dimethylsilyloxy-2-((3-bromophenoxy)methyl)propane

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1.8 h / -30 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 20.5 h / 50 °C / Inert atmosphere

3: potassium hydroxide / methanol / 1 h / 0 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium azide; triethylamine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06632c