diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate

Base Information

Chemical Name:diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate
CAS No.:1024916-46-8
Molecular Formula:C₂₈H₂₈O₅
Molecular Weight:444.527
Hs Code.:

Synonyms:diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate

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Chemical Property of diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate

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Technology Process of diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate

There total 1 articles about diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 869856-47-3
trans-(2R,3R)-2-(2-bromophenyl)-3-phenyloxirane

: 5292-53-5
diethyl benzalmalonate

: 1024916-46-8
diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate

Guidance literature:: trans-(2R,3R)-2-(2-bromophenyl)-3-phenyloxirane; With phenyllithium; In tetrahydrofuran; dibutyl ether; acetone; at -78 ℃; for 0.75h; Inert atmosphere;

diethyl benzalmalonate; In tetrahydrofuran; dibutyl ether; acetone; at -78 - 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol800437s

Reference yield: 90.0%

: 1024916-46-8
diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate

: C₂₆H₂₂O₄

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol;
DOI:10.2174/1570178617666200207105649

Reference yield: 55.0%

: 1024916-46-8
diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate

: ethyl (3S*,3aR*,8R*,8aS*)-1-oxo-3,8-diphenyl-3,3a,8,8a-tetrahydro-1H-indeno[1,2-c]furan-8a-carboxylate

Guidance literature:: diethyl ((R)-phenyl{2-[(2R,3R)-3-phenyloxiran-2-yl]phenyl}methyl)malonate; With potassium tert-butylate; In tert-butyl alcohol; at 20 ℃;

With sulfuric acid; In ethanol; at 70 ℃; optical yield given as %ee; enantiospecific reaction;
DOI:10.1021/ol800437s