4-Amino-2-methyl-3-nitropyridine

Base Information

• Chemical Name: 4-Amino-2-methyl-3-nitropyridine
• CAS No.: 27582-14-5
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90516049
• Wikidata: Q82377272
• Mol file: 27582-14-5.mol

Synonyms:4-Amino-2-methyl-3-nitropyridine;27582-14-5;2-methyl-3-nitropyridin-4-amine;4-Pyridinamine, 2-methyl-3-nitro-;4-Amino-3-nitro-2-picoline;MFCD08277309;SCHEMBL5126783;DTXSID90516049;WLZ3514;PWMOQGXCXFHJMF-UHFFFAOYSA-N;AMY10231;AKOS006288637;CS-W006814;SB75756;DS-14349;SY105066;FT-0690207;A876892;J-514336

Chemical Property of 4-Amino-2-methyl-3-nitropyridine

Chemical Property:

• Melting Point: 175 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 326.6±37.0 °C(Predicted)
• PKA: 5.54±0.42(Predicted)
• PSA: 84.73000
• Density: 1.354±0.06 g/cm3(Predicted)
• LogP: 1.98480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 153.053826475
• Heavy Atom Count: 11
• Complexity: 156

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=C1[N+](=O)[O-])N

Technology Process of 4-Amino-2-methyl-3-nitropyridine

There total 1 articles about 4-Amino-2-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-methyl-4-pyridinamine (18437-58-6) → 2-methyl-3-nitro-4-pyrimidinamine (27582-14-5) + 2-Methyl-3,5-dinitro-4-aminopyridin (27582-13-4) + 2-methyl-4-amino-5-nitropyridine (84487-12-7)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 65 ℃; for 3h;

DOI:10.1055/s-0029-1218002

Reference yield: 98.0%

acetic anhydride (108-24-7) + 2-methyl-3-nitro-4-pyrimidinamine (27582-14-5) → N-(2-methyl-3-nitro-4-pyridyl)acetamide (142078-40-8)

Guidance literature:

for 3h; Heating;

Reference yield:

2-methyl-3-nitro-4-pyrimidinamine (27582-14-5) → 7-amino-4-azaindole (142078-41-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / 3 h / Heating

2: 61 percent / 85percent aq. m-chloroperbenzoic acid / CHCl₃ / 15 h / Ambient temperature

3: 51 percent / N,N-dimethylformamide / 12 h / 90 °C

4: 49 percent / H₂ / Raney nickel / methanol / 2 h / Ambient temperature

5: 25 percent / aq. sodium hydroxide / 3 h / Heating

With sodium hydroxide; hydrogen; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; nickel; In methanol; chloroform;

upstream raw materials:

3-methyl-4-pyridinamine

Downstream raw materials:

N-(2-methyl-3-nitro-4-pyridyl)acetamide

N-(2-methyl-3-nitro-1-oxo-4-pyridyl)acetamide

7-amino-4-azaindole

2-Methyl-3,4-diamino-pyridin

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