18437-58-6Relevant articles and documents
Enthalpies of combustion of the three hydroxy-pyridines and the four hydroxy-2-methylpyridines
Suradi, S.,Saiad, Nabila el,Pilcher, G.,Skinner, H. A.
, p. 45 - 50 (1982)
The enthalpies of combustion in oxygen at 298.15 K were measured in a static-bomb calorimeter and the enthalpies of sublimation at 298.15 K were measured by microcalorimetry for the following crystalline compounds: .The derived enthalpies of formation of the gaseous compounds are compared with theoretically predicted values for certain of these compounds.
A 2 - methyl -4 - bromo pyridine preparation method
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Paragraph 0018; 0020; 0022; 0024; 0026; 0028, (2019/05/28)
The invention belongs to the field of organic synthesis, in particular relates to a 2 - methyl - 4 - bromo pyridine method, comprises the following steps: (1) malonic acid diethyl ester and alkali metal reaction to produce salt, then dropwise 2 - chloro - 4 - nitro pyridine to a toluene solution of a condensation reaction, after decarboxylation under acidic conditions shall be 2 - methyl - 4 nitro pyridine; (2) 2 - methyl - 4 - nitro-pyridine in under the catalysis of the Pd/C, methanol as the solvent, hydrogen reduction, filtered, the filtrate is concentrated, shall be 2 - methyl - 4 - aminopyridine; (3) 2 - methyl - 4 - aminopyridine first with an acid generating salt, cooled to - 10 °C - 0 °C, [...], drops the instillment sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, shall be 2 - methyl - 4 - bromo pyridine. The beneficial effect of the invention is: mild reaction conditions, is easy to operate, after treatment is simple, and easy to enlarge production, is extremely suitable for industrial production; good catalytic effect, high yield; low prices of raw materials, the production cost is low.
The synthesis of 6-deazaformycin A
Tite, Tony,Lougiakis, Nikolaos,Marakos, Panagiotis,Pouli, Nicole
scheme or table, p. 2927 - 2930 (2010/02/28)
The synthesis of the new C-nucleoside 6-deazaformycin A was achieved through the condensation of a suitably substituted lithiated 2-picoline with 2,3,5-tri-O-benzyl-d-ribonolactone, borohydride reduction of the resulting hemiacetals, followed by intramolecular Mitsunobu cyclization of the carbinols, manipulation of the protecting groups, and subsequent ring closure to result in the formation of 7-amino-3-(β-d-ribofuranosyl)pyrazolo[4,3-b]pyridine. Georg Thieme Verlag Stuttgart.
