(10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide)

Base Information

• Chemical Name: (10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide)
• CAS No.: 102651-00-3
• Molecular Formula: C₃₄H₃₁Cl₂N₉O₅
• Molecular Weight: 716.583
• Mol file: 102651-00-3.mol

Synonyms:(10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide)

Chemical Property of (10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide)

There total 2 articles about (10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-amino-4-deoxy-N10-formylpteroic acid (89043-75-4) + L-glutamic acid α-benzyl ester γ-(2,6-dichlorobenzylamide) p-toluenesulfonate salt (102651-17-2) → (10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide) (102651-00-3)

Guidance literature:

With triethylamine; isobutyl chloroformate; In water; N,N-dimethyl-formamide; for 75h; Ambient temperature;

DOI:10.1021/jm00159a023

Reference yield: 65.0%

p-nitrophenyl 4-amino-4-deoxy-N10-formylpteroate (95485-01-1) + L-glutamic acid α-benzyl ester γ-(2,6-dichlorobenzylamide) p-toluenesulfonate salt (102651-17-2) → (10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide) (102651-00-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 55 ℃; for 72h;

DOI:10.1021/jm00159a023

Reference yield: 92.0%

(10)N-formylaminopterin α-benzyl ester γ-(2,6-dichlorobenzylamide) (102651-00-3) → aminopterin γ-(2,6-dichlorobenzylamide) (102650-91-9)

Guidance literature:

With sodium hydroxide; acetic acid; In methanol; at 25 ℃; for 72h;

DOI:10.1021/jm00159a023

upstream raw materials:

4-amino-4-deoxy-N¹⁰-formylpteroic acid

L-glutamic acid α-benzyl ester γ-(2,6-dichlorobenzylamide) p-toluenesulfonate salt

p-nitrophenyl 4-amino-4-deoxy-N¹⁰-formylpteroate

Downstream raw materials:

aminopterin γ-(2,6-dichlorobenzylamide)