89043-75-4

Basic information

• Product Name: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]formylamino]-
• CAS NO: 89043-75-4
• Molecular Formula: C15H13N7O3
• Molecular Weight: 339.313
• Mol File: 89043-75-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]formylamino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]formylamino]-(89043-75-4)
• EPA Substance Registry System: Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]formylamino]-(89043-75-4)

Safety Data

• Hazardous Substances Data: 89043-75-4(Hazardous Substances Data)

Upstream product

• 119-24-4 pteroic acid 
• 54-62-6 aminopterin 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 945-24-4 2,4-diamino-6-(hydroxymethyl)pteridine 

Downstream Products

• 417703-35-6 N^α-(4-amino-4-deoxy-10-formylpteroyl)-N^δ-Boc-L-ornithinyl-L-phenylalanine tert-butyl ester 
• 130799-25-6 (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-tert-butyl ester 
• 130799-24-5 (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-5-oxo-hexanoic acid tert-butyl ester 
• 54-62-6 aminopterin 
• 89043-76-5 (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-sulfo-butyric acid methyl ester 
• 89043-76-5 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-4-sulfo-butyric acid methyl ester 
• 89043-73-2 N-(4-amino-1-deoxypteroyl)-L-homocysteic acid 
• 96193-19-0 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-sulfo-butyric acid 
• 89043-74-3 N-(4-amino-4-deoxypteroyl)-L-cysteic acid 
• 95484-99-4 α-methyl γ-tert-butyl N-(4-amino-4-deoxy-N¹⁰-formylpteroyl)-L-glutamate 
• 95485-00-0 γ-tert-butyl N-(4-amino-4-deoxy-N¹⁰-formylpteroyl)-L-glutamate 
• 89043-77-6 (R)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-3-sulfo-propionic acid methyl ester 
• 95484-98-3 γ-tert-butyl N-(4-amino-4-deoxypteroyl)-L-glutamate 
• 102650-95-3 (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid 

Relevant articles and documents

Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives

The present invention relates to pharmaceutically active ornithine compounds, particularly to pharmaceutically acceptable ammonium salts of Nδ-acyl derivatives of Nα(4-amino-4-deoxypteroyl)-L-ornithine compounds; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such ammonium salts. The ammonium salts provided by the invention exhibit superior chemical stability than corresponding acidic Nδ-acyl derivatives of Nδ-acyl derivatives of Nα(4-amino-4-deoxypteroyl)-L-ornithine compounds.

Methotrexate Analogues. 19. Replacement of the Glutamate Side Chain in Classical Antifolates by L-Homocysteic Acid and L-Cysteic Acid: Effect on Enzyme Inhibition and Antitumor Activity

Methotrexate (MTX) and aminopterin (AMT) analogues containing L-homocysteic acid or L-cysteic acid in place of L-glutamic acid were synthesized and tested as inhibitors of dihydrofolate reductase from L1210 cells and folyl polyglutamate synthetase from mo