(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

Base Information

Chemical Name:(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate
CAS No.:516494-44-3
Molecular Formula:C₁₁H₈BrNO₂
Molecular Weight:266.094
Hs Code.:

Synonyms:(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

Suppliers and Price of (E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

There total 1 articles about (E)-methyl 2-cyano-3-(4-bromophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 7677-24-9
trimethylsilyl cyanide

: 42122-27-0
(4-bromophenyl)-propynoic acid methyl ester

: 516494-44-3
(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

Guidance literature:: trimethylsilyl cyanide; With ethanol; In toluene; at 20 ℃; for 3h; Schlenk technique; Inert atmosphere;

(4-bromophenyl)-propynoic acid methyl ester; With diphenyl(methyl)phosphine; In toluene; at 20 ℃; for 24h; stereoselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.tet.2021.132457

Reference yield: 76.0%

: 1774-47-6
trimethylsulfoxonium iodide

: 516494-44-3
(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

: methyl (1RS,2SR)-2-(4-bromophenyl)-1-cyanocyclopropanecarboxylate

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 25 ℃; for 0.333333h; Inert atmosphere;

(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b04135

Reference yield: 68.0%

: 37167-59-2
dimethyl dibromomalonate

: 516494-44-3
(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate

: trimethyl 3-(4-bromophenyl)-2-cyanocyclopropane-1,1,2-tricarboxylate

Guidance literature:: dimethyl dibromomalonate; With zinc; In tetrahydrofuran; diethyl ether; for 0.0833333h; Heating;

(E)-methyl 2-cyano-3-(4-bromophenyl)acrylate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; for 1h; Further stages.; Heating;
DOI:10.1134/S1070363206120152