(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime

Base Information

Chemical Name:(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime
CAS No.:1433608-92-4
Molecular Formula:C₂₄H₂₅FN₆O
Molecular Weight:432.501
Hs Code.:

Synonyms:(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime

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Chemical Property of (R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime

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Technology Process of (R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime

There total 7 articles about (R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1433609-03-0
(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(azetidin-3-yl)oxime

: 1433608-92-4
(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1433608-97-9
(R,E)-N-Boc-3-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)azetidine

: 1433608-92-4
(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

2: sodium cyanoborohydride / methanol / 1 h / 20 °C

With sodium cyanoborohydride; trifluoroacetic acid; In methanol; dichloromethane;

Reference yield:

: 1433605-33-4
(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

: 1433608-92-4
(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(1-methylazetidin-3-yl)oxime

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 50 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3: sodium cyanoborohydride / methanol / 1 h / 20 °C

With sodium hydride; sodium cyanoborohydride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;