N-(2-Chloromethyl)-N-methylpiperidine, hydrochloride salt

Base Information

• Chemical Name: N-(2-Chloromethyl)-N-methylpiperidine, hydrochloride salt
• CAS No.: 27483-92-7
• Molecular Formula: C₇H₁₄ClN*ClH
• Molecular Weight: 184.109
• Hs Code.: 2933399090
• Mol file: 27483-92-7.mol

Synonyms:Piperidine,2-(chloromethyl)-1-methyl-, hydrochloride (7CI,8CI,9CI);1-Methyl-2-chloromethylpiperidine hydrochloride;2-Chloromethyl-1-methylpiperidine hydrochloride

Chemical Property of N-(2-Chloromethyl)-N-methylpiperidine, hydrochloride salt

Chemical Property:

• Vapor Pressure: 0.0678mmHg at 25°C
• Melting Point: 162.5-164.5℃ (acetone ethanol )
• Boiling Point: 226.2°Cat760mmHg
• Flash Point: 90.6°C
• PSA: 3.24000
• Density: g/cm³
• LogP: 2.44940
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Chloromethyl)-1-methylpiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Chloromethyl)-N-methylpiperidine, hydrochloride salt

There total 1 articles about N-(2-Chloromethyl)-N-methylpiperidine, hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(1-methyl-piperidin-2-yl)-methanol (20845-34-5) → 1-methylpiperidin-2-ylmethyl chloride hydrochloride (27483-92-7)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1021/jm050135l

Reference yield: 10.0%

7-chloro-4-hydroxy-3-phenyl-1H-quinolin-2-one (28563-19-1) + 1-methylpiperidin-2-ylmethyl chloride hydrochloride (27483-92-7) → 7-chloro-4-(1-methyl-piperidin-2-ylmethoxy)-3-phenyl-1H-quinolin-2-one + 7-chloro-4-(1-methyl-azepan-3-yloxy)-3-phenyl-1H-quinolin-2-one

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

DOI:10.1016/S0960-894X(99)00446-1

Reference yield:

1-methylpiperidin-2-ylmethyl chloride hydrochloride (27483-92-7) → (-)-2-iodophenyl-[2-methyl-1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl]methanone

Guidance literature:

Multi-step reaction with 3 steps

1.1: KOH / dimethylsulfoxide / 4 h / 80 °C / Heating

1.2: 63 percent / dimethylsulfoxide / Heating

2.1: 83 percent / AlCl₃ / CH₂Cl₂ / 40 °C

3.1: chiral HPLC

With potassium hydroxide; aluminium trichloride; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm050135l

upstream raw materials:

(1-methyl-piperidin-2-yl)-methanol

Downstream raw materials:

(2-iodo-phenyl)-[2-methyl-1-(1-methyl-piperidin-2-ylmethyl)-1H-indol-3-yl]-methanone

3-(1-methyl-3-hexahydroazepinyloxy)benzaldehyde

Refernces

• 1、 -. "Substituted anilino-quinazoline (or quinoline) compounds and use thereof". . . Retrieved 2008/06/13.