(1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol

Base Information

Chemical Name:(1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol
CAS No.:642454-61-3
Molecular Formula:C₂₅H₃₆O₄Si
Molecular Weight:428.644
Hs Code.:

Synonyms:(1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol

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Technology Process of (1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol

There total 10 articles about (1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 642454-47-5
(1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentyl benzoate

: 642454-61-3
(1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -75 ℃; for 0.5h;
DOI:10.1271/bbb.67.1959

Reference yield:

: 642454-68-0
Benzoic acid (1S,2S)-2-(2-oxo-ethyl)-cyclopentyl ester

: 642454-61-3
(1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 74 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene; 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 0 °C

2.1: 4-methylmorpholine N-oxide; OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 18 h / 20 °C

2.2: 3.50 g / NaBH₄ / ethanol / 3 h / 20 °C

3.1: 100 percent / triethylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 20 °C

4.1: 91 percent / (i-Pr)2NEt / CH₂Cl₂ / 18 h / 20 °C

5.1: 88 percent / DIBAL / toluene / 0.5 h / -75 °C

With dmap; osmium(VIII) oxide; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1271/bbb.67.1959

Reference yield:

: 642454-41-9
(1S,2S)-2-(2-hydroxyethyl)cyclopentyl benzoate

: 642454-61-3
(1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 78 percent / pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 18 h / 20 °C

2.1: 74 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene; 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 0 °C

3.1: 4-methylmorpholine N-oxide; OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 18 h / 20 °C

3.2: 3.50 g / NaBH₄ / ethanol / 3 h / 20 °C

4.1: 100 percent / triethylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 20 °C

5.1: 91 percent / (i-Pr)2NEt / CH₂Cl₂ / 18 h / 20 °C

6.1: 88 percent / DIBAL / toluene / 0.5 h / -75 °C

With dmap; osmium(VIII) oxide; sodium acetate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In dichloromethane; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1271/bbb.67.1959