4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Base Information

Chemical Name:4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride
CAS No.:1456621-43-4
Molecular Formula:C₂₁H₂₂Cl₂N₄O₃*ClH
Molecular Weight:485.798
Hs Code.:

Synonyms:4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

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Chemical Property of 4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

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Technology Process of 4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

There total 8 articles about 4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 13686-19-6
N¹,N¹-bis(2-chloroethyl)benzene-1,3-diamine

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1456621-43-4
4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Guidance literature:: In isopropyl alcohol; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

: 100905-33-7
ethyl 2-nitro-4,5-dimethoxybenzoate

: 1456621-43-4
4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen; palladium on activated charcoal / methanol

2: 165 - 170 °C

3: L-methionine / methanesulfonic acid / 120 °C

4: dmap / pyridine

5: trichlorophosphate / toluene / Reflux

6: isopropyl alcohol / 1 h / Inert atmosphere; Reflux

With dmap; L-methionine; palladium on activated charcoal; hydrogen; trichlorophosphate; In pyridine; methanol; methanesulfonic acid; isopropyl alcohol; toluene;
DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

: 3943-77-9
ethyl veratrate

: 1456621-43-4
4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; nitric acid / 0 °C

2: hydrogen; palladium on activated charcoal / methanol

3: 165 - 170 °C

4: L-methionine / methanesulfonic acid / 120 °C

5: dmap / pyridine

6: trichlorophosphate / toluene / Reflux

7: isopropyl alcohol / 1 h / Inert atmosphere; Reflux

With dmap; L-methionine; palladium on activated charcoal; hydrogen; nitric acid; acetic acid; trichlorophosphate; In pyridine; methanol; methanesulfonic acid; isopropyl alcohol; toluene;
DOI:10.1016/j.ejmech.2013.06.055