(1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane

Base Information

Chemical Name:(1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane
CAS No.:197246-67-6
Molecular Formula:C₂₄H₃₃IO₂Si
Molecular Weight:508.515
Hs Code.:

Synonyms:(1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane

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Chemical Property of (1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane

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Technology Process of (1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane

There total 3 articles about (1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid (1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexylmethyl ester

: 197246-67-6
(1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane

Guidance literature:: With lithium iodide; In tetrahydrofuran; at 0 ℃; for 2h; Heating;
DOI:10.1016/S0040-4020(97)00865-X

Reference yield:

: 143347-70-0
(1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-3-methoxy-cyclohexanemethanol

: 197246-67-6
(1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 °C

2: 3.90 g / LiI / tetrahydrofuran / 2 h / 0 °C / Heating

With triethylamine; lithium iodide; In tetrahydrofuran; 1: Esterification / 2: Substitution;
DOI:10.1016/S0040-4020(97)00865-X

Reference yield:

: 143347-69-7
(1R,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexanecarboxylic acid methyl ester

: 197246-67-6
(1R,3R,4R)-4-[((1,1-dimethylethyl)diphenylsilyl)-oxy]-1-(iodomethyl)-3-methoxy-cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / LAH / diethyl ether / 1.75 h / 0 °C

2: triethylamine / tetrahydrofuran / 1 h / 0 °C

3: 3.90 g / LiI / tetrahydrofuran / 2 h / 0 °C / Heating

With lithium aluminium tetrahydride; triethylamine; lithium iodide; In tetrahydrofuran; diethyl ether; 1: Reduction / 2: Esterification / 3: Substitution;
DOI:10.1016/S0040-4020(97)00865-X