(E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione

Base Information

Chemical Name:(E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione
CAS No.:702697-21-0
Molecular Formula:C₂₁H₂₁ClN₄O₃
Molecular Weight:412.876
Hs Code.:

Synonyms:(E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione

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Chemical Property of (E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione

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Technology Process of (E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione

There total 10 articles about (E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 261717-18-4
[3H]-MSX 2

: phosphoric acid mono-(3-(8-[2-(3-methoxyphenyl)vinyl]-7-methyl-2,6-dioxo-1-prop-2-ynyl-1,2,6,7-tetrahydropurin-3-yl)propyl) ester

: 702697-21-0
(E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione

Guidance literature:: With trimethyl phosphite; trichlorophosphate; at 20 ℃; for 0.5h;
DOI:10.1021/jo0358574

Reference yield:

: 138895-22-4
6-amino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 702697-21-0
(E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / acetic acid; NaNO₂ / H₂O / 65 °C

2: 67 percent / NH₃; sodium dithionite / H₂O / 0.17 h / 70 °C

3: 80 percent / pyridine / ethyl acetate / 16 h / 20 °C

4: 90 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

5: (NH₂)2SO₄ / 16 h / Heating

6: 93 percent / K₂CO₃ / dimethylformamide / 5 h / 20 °C

7: trimethyl phospate; POCl₃ / 0.5 h / 20 °C

With pyridine; trimethyl phosphite; sodium dithionite; amino sulphate; ammonia; potassium carbonate; acetic acid; sodium nitrite; trichlorophosphate; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0358574

Reference yield:

: 146830-70-8
6-amino-5-nitroso-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 702697-21-0
(E)-3-(3-chloropropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / NH₃; sodium dithionite / H₂O / 0.17 h / 70 °C

2: 80 percent / pyridine / ethyl acetate / 16 h / 20 °C

3: 90 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

4: (NH₂)2SO₄ / 16 h / Heating

5: 93 percent / K₂CO₃ / dimethylformamide / 5 h / 20 °C

6: trimethyl phospate; POCl₃ / 0.5 h / 20 °C

With pyridine; trimethyl phosphite; sodium dithionite; amino sulphate; ammonia; potassium carbonate; trichlorophosphate; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo0358574