(S)-4-(4-iodophenoxy)butane-1,2-diol

Base Information

• Chemical Name: (S)-4-(4-iodophenoxy)butane-1,2-diol
• CAS No.: 1088780-64-6
• Molecular Formula: C₁₀H₁₃IO₃
• Molecular Weight: 308.116
• Mol file: 1088780-64-6.mol

Synonyms:(S)-4-(4-iodophenoxy)butane-1,2-diol

Chemical Property of (S)-4-(4-iodophenoxy)butane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(4-iodophenoxy)butane-1,2-diol

There total 2 articles about (S)-4-(4-iodophenoxy)butane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-4-(2-(4-iodophenoxy)ethyl)-2,2-dimethyl-1,3-dioxolane (1088780-69-1) → (S)-4-(4-iodophenoxy)butane-1,2-diol (1088780-64-6)

Guidance literature:

With water; acetic acid; at 20 ℃; for 24h;

DOI:10.1039/b808564a

Reference yield:

p-Iodophenol (540-38-5) → (S)-4-(4-iodophenoxy)butane-1,2-diol (1088780-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran

2: acetic acid / water

With acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; 1: |Mitsunobu Displacement;

DOI:10.1080/15257770.2013.765013

Reference yield: 95.0%

(S)-4-(4-iodophenoxy)butane-1,2-diol (1088780-64-6) + trimethylsilylacetylene (1066-54-2) → (S)-4-(4-((trimethylsilyl)ethynyl)phenoxy)butane-1,2-diol (1427039-95-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 24h; Inert atmosphere;

DOI:10.1080/15257770.2013.765013

upstream raw materials:

(S)-4-(2-(4-iodophenoxy)ethyl)-2,2-dimethyl-1,3-dioxolane

p-Iodophenol

Downstream raw materials:

(S)-4-(4-(pyren-1-ylethynyl)phenoxy)butane-1,2-diol

(S)-4-(4-((trimethylsilyl)ethynyl)phenoxy)butane-1,2-diol

(S)-4-(4-ethynylphenoxy)butane-1,2-diol

(S)-4-(4-((6-(2-(dimethylamino)ethyl)-6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)phenoxy)butane-1,2-diol