methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate

Base Information

Chemical Name:methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate
CAS No.:896448-48-9
Molecular Formula:C₂₆H₃₇N₃O₇
Molecular Weight:503.596
Hs Code.:

Synonyms:methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate

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Chemical Property of methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate

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Technology Process of methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate

There total 4 articles about methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 874960-47-1
methyl 2-(S)-amino-3-(4-dimethylcarbamoyloxyphenyl)propanoate

: 109523-16-2
(2S)-3-tert-butoxycarbonyl-3-azabicyclo[2.2.2]octane-2-carboxylic acid

: 896448-48-9
methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 0 - 23 ℃; for 17h;
DOI:10.1016/j.bmc.2006.01.067

Reference yield:

: (S)-2-azabicyclo[2.2.2]octane-3-carboxylic acid hydrochloride

: 896448-48-9
methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / NaOH / dioxane / 5 h / 0 - 23 °C

2: 60 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 17 h / 0 - 23 °C

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2006.01.067

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 896448-48-9
methyl 2-(S)-[(2-(S)-N-(t-butyloxycarbonyl)azabicyclo[2.2.2]octane-3-carbonyl)amino]-3-(4-dimethylcarbamoyloxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / NaOH / dioxane / 5 h / 0 - 23 °C

2: 60 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 17 h / 0 - 23 °C

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2006.01.067