874960-47-1Relevant academic research and scientific papers
Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent
Lawson, Edward C.,Santulli, Rosemary J.,Dyatkin, Alexey B.,Ballentine, Scott A.,Abraham, William M.,Rudman, Sandra,Page, Clive P.,de Garavilla, Lawrence,Damiano, Bruce P.,Kinney, William A.,Maryanoff, Bruce E.
, p. 4208 - 4216 (2007/10/03)
The α4β1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent α4β1 antagonists that we evaluated for
BICYCLIC TRIAZOLE A4 INTEGRIN INHIBITORS
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Page/Page column 39-41, (2008/06/13)
The compounds of the present invention are novel bicyclic triazole amino acid-derivatives useful as a4 integrin receptor antagonists. The invention is further directed to methods for treating integrin mediated disorders including, but not limited to, infl
