1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid
CAS No.:1361236-28-3
Molecular Formula:C₁₆H₁₈N₂O₄
Molecular Weight:302.33
Hs Code.:

Synonyms:1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

There total 4 articles about 1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1361236-20-5
1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

: 1361236-28-3
1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Guidance literature:: With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; tert-butyl alcohol; In water; at 0 - 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm201331s

Reference yield:

: 5337-03-1
tetrahydro-2H-pyran-4-carboxylic acid

: 1361236-28-3
1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: pyridine; acetic acid / water / 0.08 h / Inert atmosphere

2.2: 2 h / 105 °C / Inert atmosphere

3.1: trichlorophosphate / 0.75 h / 0 °C / Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

4.1: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; tert-butyl alcohol / water / 48 h / 0 - 20 °C / Inert atmosphere

With pyridine; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; acetic acid; 1,1'-carbonyldiimidazole; tert-butyl alcohol; trichlorophosphate; In tetrahydrofuran; water; 2.1: Knorr condensation / 3.1: Vilsmeier-Haack reaction / 3.2: Vilsmeier-Haack reaction / 4.1: Pinnick oxidation;
DOI:10.1021/jm201331s

Reference yield:

: 110238-91-0
tetrahydropyran-4-carboxylic acid methyl ester

: 1361236-28-3
1-methyl-3-oxo-2-phenyl-5-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 0.17 h / -10 °C / Inert atmosphere

1.2: 5.33 h / -10 - 20 °C / Inert atmosphere

1.3: pH 2 - 3 / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: pyridine; acetic acid / water / 0.08 h / Inert atmosphere

3.2: 2 h / 105 °C / Inert atmosphere

4.1: trichlorophosphate / 0.75 h / 0 °C / Inert atmosphere

4.2: 48 h / 20 °C / Inert atmosphere

5.1: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; tert-butyl alcohol / water / 48 h / 0 - 20 °C / Inert atmosphere

With pyridine; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; acetic acid; 1,1'-carbonyldiimidazole; tert-butyl alcohol; trichlorophosphate; In tetrahydrofuran; methanol; water; 3.1: Knorr condensation / 4.1: Vilsmeier-Haack reaction / 4.2: Vilsmeier-Haack reaction / 5.1: Pinnick oxidation;
DOI:10.1021/jm201331s