(2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine

Base Information

Chemical Name:(2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine
CAS No.:110005-26-0
Molecular Formula:C₃₀H₄₃NO₄P₂S
Molecular Weight:575.689
Hs Code.:

Synonyms:(2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine

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Technology Process of (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine

There total 13 articles about (2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4376-01-6
sodium diphenylphosphide

: 110005-26-0
(2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / tetrahydrofuran; dioxane / a) 0 deg C, 2 h, b) RT, overnight

2: 10percent aq. H₂O₂ / methanol / a) 0 deg C, 1 h, b) RT, 1 h

3: HCl gas / methanol / 2 h / Ambient temperature

4: 91 percent / H₂, 5percent Rh on Al₂O₃ powder / methanol / 48 h / 150 °C / 114000 Torr

5: 96 percent / pyridine / a) 0 deg C, 3 h, b) RT, 14 h

6: dimethylformamide; dioxane; tetrahydrofuran / 13 h / -20 °C

7: 10percent aq.H₂O₂ / methanol / a) 0 deg C, 0.5 h, b) RT, 0.5 h

With pyridine; hydrogenchloride; rhodium on alumina; hydrogen; dihydrogen peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.481

Reference yield:

: 110005-21-5
(3R-trans)-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-(methylsulfonyl)-3-pyrrolidinol methanesulfonate

: 110005-26-0
(2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / tetrahydrofuran; dioxane / a) 0 deg C, 2 h, b) RT, overnight

2: 10percent aq. H₂O₂ / methanol / a) 0 deg C, 1 h, b) RT, 1 h

3: HCl gas / methanol / 2 h / Ambient temperature

4: 91 percent / H₂, 5percent Rh on Al₂O₃ powder / methanol / 48 h / 150 °C / 114000 Torr

5: 96 percent / pyridine / a) 0 deg C, 3 h, b) RT, 14 h

6: dimethylformamide; dioxane; tetrahydrofuran / 13 h / -20 °C

7: 10percent aq.H₂O₂ / methanol / a) 0 deg C, 0.5 h, b) RT, 0.5 h

With pyridine; hydrogenchloride; rhodium on alumina; hydrogen; dihydrogen peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.481

Reference yield:

: 110005-20-4
(3R-trans)-5-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-(methylsulfonyl)-3-pyrrolidinol

: 110005-26-0
(2S-cis)-4-(dicyclohexylphosphinyl)-2-<(diphenylphosphinyl)-methyl>-1-(methylsulfonyl)-2-pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / anh. pyridine / 15 h / Ambient temperature

2: 70 percent / tetrahydrofuran; dioxane / a) 0 deg C, 2 h, b) RT, overnight

3: 10percent aq. H₂O₂ / methanol / a) 0 deg C, 1 h, b) RT, 1 h

4: HCl gas / methanol / 2 h / Ambient temperature

5: 91 percent / H₂, 5percent Rh on Al₂O₃ powder / methanol / 48 h / 150 °C / 114000 Torr

6: 96 percent / pyridine / a) 0 deg C, 3 h, b) RT, 14 h

7: dimethylformamide; dioxane; tetrahydrofuran / 13 h / -20 °C

8: 10percent aq.H₂O₂ / methanol / a) 0 deg C, 0.5 h, b) RT, 0.5 h

With pyridine; hydrogenchloride; rhodium on alumina; hydrogen; dihydrogen peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.481