cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

Base Information

Chemical Name:cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
CAS No.:79560-05-7
Molecular Formula:C₁₈H₂₁NO*ClH
Molecular Weight:303.832
Hs Code.:

Synonyms:cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

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Chemical Property of cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

Chemical Property:

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Technology Process of cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

There total 8 articles about cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 79560-31-9
N-methyl-4-(4-methoxyphenyl)-1,2-dihydro-1-naphthalenamine hydrochloride

: 79560-05-7
cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

: 79836-63-8
trans-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 4h; under 2327.2 Torr; Ambient temperature;
DOI:10.1021/jm00377a021

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 79560-05-7
cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) magnesium / 1.) THF, 55 deg C, 2 h, 2.) THF, RT, 16 h

2: 67 percent / toluenesulfonic acid / toluene / 16 h / Heating

3: 92.5 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 2585.7 Torr / Ambient temperature

4: 23 percent / KMnO₄, water / acetone / 80 h / Heating

5: TiCl₄ / tetrahydrofuran / 16 h / Ambient temperature

6: sodium borohydride / ethanol / 1 h / Ambient temperature

7: 72 percent / HCl (gas) / diethyl ether

8: 15 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; o-toluenesulfonic acid; water; hydrogen; titanium tetrachloride; magnesium; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; acetone; toluene;
DOI:10.1021/jm00377a021

Reference yield:

: 21855-80-1
4-(3,4-dihydronaphthalen-1-yl)phenyl methyl ether

: 79560-05-7
cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 92.5 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 2585.7 Torr / Ambient temperature

2: 23 percent / KMnO₄, water / acetone / 80 h / Heating

3: TiCl₄ / tetrahydrofuran / 16 h / Ambient temperature

4: sodium borohydride / ethanol / 1 h / Ambient temperature

5: 72 percent / HCl (gas) / diethyl ether

6: 15 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; water; hydrogen; titanium tetrachloride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; acetone;
DOI:10.1021/jm00377a021