21855-80-1

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 79560-27-3 1-hydroxy-1-(4-methoxyphenyl)tetralin 
• 104-15-4 toluene-4-sulfonic acid 
• 1072840-85-7 3,4-dihydronaphthalen-1-yl pivalate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 149512-01-6 1,2-dihydro-4-iodonaphthalene 

Downstream Products

• 27331-33-5 1-(4-methoxyphenyl)naphthalene 
• 855409-38-0 4-(3,4-Dihydro-[1]naphthyl)-phenol 
• 19353-89-0 1-(4-methoxyphenyl)-1,2,3,4-tetrahydronaphthalene 
• 3771-17-3 4-(1,2,3,4-tetrahydro-1-naphthyl)-phenol 
• 117266-87-2 2-(p-anisoyl)phenylpropionic acid 
• 79836-63-8 trans-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride 
• 79560-05-7 cis-N-methyl-4-(methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride 
• 79560-31-9 N-methyl-4-(4-methoxyphenyl)-1,2-dihydro-1-naphthalenamine hydrochloride 
• 79560-29-5 N-methyl-4-hydroxy-4-(4-methoxyphenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 79560-28-4 4-hydroxy-4-(4-methoxyphenyl)-1-tetralone 
• 1046113-15-8 7b-(4-methoxyphenyl)-1a,2,3,7b-tetrahydro-1-oxacyclopropa[a ]naphthalene 

Relevant academic research and scientific papers

Solid phase synthesizing method of dihydronaphthalene compound

A solid phase synthesizing method of a dihydronaphthalene compound I belongs to the field of organic chemistry and comprises: 1, using 1% crosslinked polystyrene resin as a carrier to prepare a polystyrene-loaded selenium base succinimide reagent III; 2, under catalyzing of fluoroform sulfonic acid trimethyl estersil, using the III to induce olefin V to be subjected to intramolecular cyclization to form 3-polystyrene-loaded selenium base-1,2,3,4-tetrahydronaphthalene VI; 3, removing VI by an oxidant through oxidation without further separating, thereby directly obtaining dihydronaphthalene I. Raw materials are easy to obtain, the product yield is good, the purity is high, the operation is simple and convenient, the posttreatment is simple and the method has well industrial application prospect.

Cu-catalyzed intramolecular hydroarylation of alkynes

An efficient Cu-catalyzed intramolecular hydroarylation reaction of alkynes has been developed. The reaction is accomplished under mild conditions and shows good tolerance to both electron-rich and electron-deficient aryl nucleophiles. A series of aryl, h

A mild dihydrobenzooxaphosphole oxazoline/iridium catalytic system for asymmetric hydrogenation of unfunctionalized dialins

Air-stable P-chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium-catalyzed asymmetric hydrogenation of unfunctionalized 1-aryl-3,4-dihydronaphthalenes under one atmosphere pressure of H2, up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1-tetralones.

Atom-efficient vinylic arylations with triarylbismuths as substoichiometric multicoupling reagents under palladium catalysis

The first atom-efficient arylation of vinylic iodides was achieved by using triarylbismuths as substoichiometric multicoupling reagents under palladium catalysis. Vinylic iodides were efficiently coupled with electronically divergent triarylbismuths to furnish the corresponding arylated products in short reaction times.

A one-pot preparation of aryl- and heteroarylcycloalkenes: Application to the total synthesis of (±)-laurokamurene B

A general one-pot method has been developed for the preparation of various aryl- and heteroarylcycloalkenes. After lithiation of aryl and heteroaryl bromides followed by transmetalation with CeCl3, the organocerium addition to cycloalkanones proceeds clea

FeCl3-catalyzed intramolecular hydroarylation of alkynes

The intramolecular hydroarylation of alkynes using a substoichiometric amount of FeCl3 is described. When starting from tetrasubstituted substrates, products resulting from an unexpected toluene (or xylene) elimination are isolated in good yields.

Arylation and vinylation of alkenes based on unusual sequential semipinacol rearrangement/Grob fragmentation of allylic alcohols

(Chemical Equation Presented) Alkenes can be stereoselectively arylated and vinylated without transition-metal catalyst under mild conditions through an interesting NBS-promoted semipinacol rearrangement and a subsequent unusual NaOH-mediated Grob fragmentation.

Cross-coupling reactions of aryl pivalates with boronic acids

The first cross-coupling of acylated phenol derivatives has been achieved. In the presence of an air-stable Ni(II) complex, readily accessible aryl pivalates participate in the Suzuki-Miyaura coupling with arylboronic acids. The process is tolerant of considerable variation in each of the cross-coupling components. In addition, a one-pot acylation/cross-coupling sequence has been developed. The potential to utilize an aryl pivalate as a directing group has also been demonstrated, along with the ability to sequentially cross-couple an aryl bromide followed by an aryl pivalate, using palladium and nickel catalysis, respectively. Copyright

BIPHENYL INTEGRIN ANTAGONISTS

The following invention is directed to pharmaceutical compounds and compositions of the Formula (I). useful for treating conditions mediated by αVβ3 and/or αVβ5 integrin.

Dynamic kinetic resolution-asymmetric transfer hydrogenation of 1-aryl-substituted cyclic ketones

A range of 1-aryl-2-tetranols, and 1-phenyl-2-indanol, have been generated in high yield and enantiomeric excess from the corresponding racemic ketones, via a dynamic kinetic resolution-transfer hydrogenation process, using Ru(II)-TsDPEN in formic acid/triethylamine (5:2). This provides a potential entry to an asymmetric total synthesis of benzazepines such as Sch 39166.