methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate

Base Information

• Chemical Name: methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate
• CAS No.: 1443792-02-6
• Molecular Formula: C₃₁H₃₈N₂O₅S
• Molecular Weight: 550.719
• Mol file: 1443792-02-6.mol

Synonyms:methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate

Chemical Property of methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate

There total 2 articles about methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)benzaldehyde (1443792-01-5) + trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate (121056-95-9,89524-98-1) → methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate (1443792-02-6)

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at -70 - 20 ℃; for 19h; Inert atmosphere;

Reference yield:

4-n-heptyloxybromobenzene (123732-04-7) → methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate (1443792-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Trimethylacetic acid; tricyclohexylphosphine; palladium diacetate; potassium carbonate / N,N-dimethyl acetamide / 6 h / 100 °C / Inert atmosphere

2: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 19 h / -70 - 20 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; Trimethylacetic acid; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield: 29.0%

methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)acrylate (1443792-02-6) → methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)propanoate (1443792-03-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 40 ℃;

upstream raw materials:

4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)benzaldehyde

trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

4-n-heptyloxybromobenzene

Downstream raw materials:

methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(5-(4-(heptyloxy)phenyl)thiazol-2-yl)phenyl)propanoate