ethyl 3-bromo-5-cyanobenzoate

Base Information

• Chemical Name: ethyl 3-bromo-5-cyanobenzoate
• CAS No.: 1229442-86-7
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.083
• Mol file: 1229442-86-7.mol

Synonyms:ethyl 3-bromo-5-cyanobenzoate

Chemical Property of ethyl 3-bromo-5-cyanobenzoate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl3-bromo-5-cyanobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-bromo-5-cyanobenzoate

There total 3 articles about ethyl 3-bromo-5-cyanobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

→ ethyl 3-bromo-5-cyanobenzoate (1229442-86-7)

Guidance literature:

Reference yield:

zinc(II) cyanide (557-21-1) + ethyl 3-bromo-5-iodobenzoate (186772-44-1) → ethyl 3-bromo-5-cyanobenzoate (1229442-86-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00829

Reference yield:

3-bromo-5-iodo-benzoic acid (188815-32-9) → ethyl 3-bromo-5-cyanobenzoate (1229442-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 5 h / 90 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.6b00829

upstream raw materials:

3-bromo-5-iodo-benzoic acid

zinc(II) cyanide

ethyl 3-bromo-5-iodobenzoate

Downstream raw materials:

ethyl 3-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

5-cyano-N-cyclopropyl-3'-(5-(3-(3,5-dichloropyridin-4-yl)ureido)-1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-[1,1'-biphenyl]-3-carboxamide

Refernces

• 1、 -. "(3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors". Page/Page column 62; 63. . Retrieved 2010/07/03.