4-CHLORO-1-METHYL-1H-PYRROLO[3,2-C]PYRIDINE

Base Information

• Chemical Name: 4-CHLORO-1-METHYL-1H-PYRROLO[3,2-C]PYRIDINE
• CAS No.: 27382-01-0
• Molecular Formula: C8H7ClN2
• Molecular Weight: 166.61
• Hs Code.: 2933990090
• Mol file: 27382-01-0.mol

Synonyms:4-Chloro-1-methyl-5-azaindole;

Chemical Property of 4-CHLORO-1-METHYL-1H-PYRROLO[3,2-C]PYRIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.633
• Boiling Point: 312.026 °C at 760 mmHg
• PKA: 5.27±0.10(Predicted)
• Flash Point: 142.509 °C
• PSA: 17.82000
• Density: 1.3 g/cm³
• LogP: 2.22670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-1-methyl-1H-pyrrolo[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-1-METHYL-1H-PYRROLO[3,2-C]PYRIDINE

There total 3 articles about 4-CHLORO-1-METHYL-1H-PYRROLO[3,2-C]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloro-1H-pyrrolo-[3,2-c]-pyridine (60290-21-3) + methyl iodide (74-88-4) → 1-methyl-4-chloro-1H-pyrrolo<3,2-c>pyridine (27382-01-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.1c00720

Reference yield: 57.0%

1-methyl-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (27381-99-3) → 1-methyl-4-chloro-1H-pyrrolo<3,2-c>pyridine (27382-01-0)

Guidance literature:

With trichlorophosphate; Heating;

DOI:10.1021/jm00126a002

Reference yield:

→ 1-methyl-4-chloro-1H-pyrrolo<3,2-c>pyridine (27382-01-0)

Guidance literature:

13, POCl3;

DOI:10.1016/S0040-4020(01)92786-3

upstream raw materials:

1-methyl-1H-pyrrolo[3,2-c]pyridin-4(5H)-one

4-chloro-1H-pyrrolo-[3,2-c]-pyridine

methyl iodide

Downstream raw materials:

4-chloro-3-formyl-1-methylpyrrolo<3,2-c>pyridine

methyl-1 formyl-2 chloro-4 pyrrolo<3,2-c>pyridine

1-benzyl-4-methylamino-1H-pyrrolo<2,3-b>pyridine

benzyl-(1-methyl-1H-pyrrolo[3,2-c]pyridin-4-yl)-amine

Refernces

• 1、 New, James S.,Christopher, William L.,Yevich, Joseph P.,Butler, Rhett,Schlemmer, R. Francis,et al.. "The Thienopyridine and Furopyridine Rings: New Pharmacophores with Potential Antipsychotic Activity". . p. 1147 - 1156. Retrieved 2007/10/02.