6-(2,4-difluorophenyl)-5-fiuoropicolinic acid

Base Information

• Chemical Name: 6-(2,4-difluorophenyl)-5-fiuoropicolinic acid
• CAS No.: 1210418-87-3
• Molecular Formula: C₁₂H₆F₃NO₂
• Molecular Weight: 253.18
• Mol file: 1210418-87-3.mol

Synonyms:6-(2,4-difluorophenyl)-5-fiuoropicolinic acid

Chemical Property of 6-(2,4-difluorophenyl)-5-fiuoropicolinic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 6-(2,4-difluorophenyl)-5-fiuoropicolinic acid

There total 3 articles about 6-(2,4-difluorophenyl)-5-fiuoropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

6-bromo-5-fluoro-pyridine-2-carboxylic acid (1052714-46-1) + 2,4-difluorophenylboronic acid (144025-03-6) → 6-(2,4-difluorophenyl)-5-fiuoropicolinic acid (1210418-87-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield: 79.0%

→ 6-(2,4-difluorophenyl)-5-fiuoropicolinic acid (1210418-87-3)

Guidance literature:

Reference yield:

2-bromo-3-fluoro-6-methylpyridine (374633-36-0) → 6-(2,4-difluorophenyl)-5-fiuoropicolinic acid (1210418-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate / water / 53 h / 100 °C

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

With potassium permanganate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; water;

upstream raw materials:

6-bromo-5-fluoro-pyridine-2-carboxylic acid

2,4-difluorophenylboronic acid

2-bromo-3-fluoro-6-methylpyridine

Refernces

• 1、 -. "Kinase inhibitors and methods of their use". Page/Page column 42. . Retrieved 2010/04/23.