Technology Process of 1,4-anhydro-2-deoxy-2-fluoro-3,5-di-O-benzoyl-4-thio-D-arabinitol
There total 11 articles about 1,4-anhydro-2-deoxy-2-fluoro-3,5-di-O-benzoyl-4-thio-D-arabinitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / tetrahydrofuran / 0 - 10 °C
2.1: sodium sulfide / 1-methyl-pyrrolidin-2-one / 80 °C
3.1: water; sulfuric acid / tetrahydrofuran / 70 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 - 2 h / 0 °C
4.2: 0 - 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 - 30 °C
5.2: 50 °C / pH 1
5.3: 20 °C / pH 7 - 10
6.1: boron trichloride / dichloromethane / 0.5 h / -65 °C
6.2: 0.25 h / -65 - 20 °C
7.1: pyridine / dichloromethane / 10 - 20 °C
7.2: 1 h
With
pyridine; sodium sulfide; sulfuric acid; tetrabutyl ammonium fluoride; water; boron trichloride; sodium hydride; triethylamine;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: water; sulfuric acid / tetrahydrofuran / 70 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 - 2 h / 0 °C
2.2: 0 - 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 - 30 °C
3.2: 50 °C / pH 1
3.3: 20 °C / pH 7 - 10
4.1: boron trichloride / dichloromethane / 0.5 h / -65 °C
4.2: 0.25 h / -65 - 20 °C
5.1: pyridine / dichloromethane / 10 - 20 °C
5.2: 1 h
With
pyridine; sulfuric acid; tetrabutyl ammonium fluoride; water; boron trichloride; sodium hydride;
In
tetrahydrofuran; dichloromethane; mineral oil;
