Benzenesulfonamide, 2-(cyanomethyl)- (9CI)

Base Information

• Chemical Name: Benzenesulfonamide, 2-(cyanomethyl)- (9CI)
• CAS No.: 27350-01-2
• Molecular Formula: C8H8 N2 O2 S
• Molecular Weight: 196.23
• Hs Code.: 2935009090
• Mol file: 27350-01-2.mol

Synonyms:o-Toluenesulfonamide,a-cyano- (8CI)

Chemical Property of Benzenesulfonamide, 2-(cyanomethyl)- (9CI)

Chemical Property:

• PSA: 92.33000
• LogP: 2.18118

Purity/Quality:

99% ^*data from raw suppliers

2-(Cyanomethyl)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenesulfonamide, 2-(cyanomethyl)- (9CI)

There total 2 articles about Benzenesulfonamide, 2-(cyanomethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyanomethyl-benzenesulfonyl chloride (27350-00-1) → 2-cyanomethyl-benzenesulfonamide (27350-01-2)

Guidance literature:

With ammonium hydroxide; In acetonitrile; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.02.054

Reference yield:

→ 2-cyanomethyl-benzenesulfonamide (27350-01-2)

Guidance literature:

Sulfochlorid 3, Ammoniak;

DOI:10.1002/cber.19701030638

Reference yield:

2-cyanomethyl-benzenesulfonamide (27350-01-2) → 2H-1,2-benzothiazin-3(4H)-one,1,1-dioxide (27363-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / 16 h

2: aq. NaOH / 4 h / Heating

With sodium hydroxide; sulfuric acid;

DOI:10.1002/cber.19701030638

upstream raw materials:

2-cyanomethyl-benzenesulfonyl chloride

Downstream raw materials:

2H-1,2-benzothiazin-3(4H)-one,1,1-dioxide

Refernces

• 1、 Sianesi,Redaelli,Bertani,Da Re. "New benzothiazines. II. 2H-1,2-benzothiazin-3(4H)-one 1,1-dioxide and 1H-2,3-benzothiazin-4(3H)-one 2,2-dioxide". . p. 1992 - 2002. Retrieved 2007/10/05.