tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate
CAS No.:1341218-03-8
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate

Chemical Property:

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Technology Process of tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate

There total 2 articles about tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 70-11-1
α-bromoacetophenone

: 151367-92-9
L-tert-butyl N-[2,6-dioxohexahydro-3-pyridinyl] Carbamate

: 1341218-03-8
tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate

Guidance literature:: With potassium carbonate; potassium iodide; In acetone; for 0.25h; Reflux;
DOI:10.1002/cjoc.201180248

Reference yield:

: 13726-85-7
Boc-Gln-OH

: 1341218-03-8
tert-butyl (S)-2,6-dioxo-1-(2-oxo-2-phenylethyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 49 h / 0 - 20 °C

2: potassium carbonate; potassium iodide / acetone / 0.25 h / Reflux

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; In dichloromethane; acetone;
DOI:10.1002/cjoc.201180248