N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide

Base Information

Chemical Name:N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide
CAS No.:1332892-46-2
Molecular Formula:C₁₈H₁₆N₂O₄
Molecular Weight:324.336
Hs Code.:

Synonyms:N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide

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Chemical Property of N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide

Chemical Property:

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Technology Process of N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide

There total 9 articles about N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₀N₂O₄Si

: 1332892-46-2
N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 0.5h;

Reference yield:

: 496-41-3
Benzofuran-2-carboxylic acid

: 1332892-46-2
N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.1: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

3.2: 2 h / 20 °C

4.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; HATU; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;

Reference yield:

: 65874-27-3
4-(tert-butoxycarbonyl)benzaldehyde

: 1332892-46-2
N-((1R)-1-{4-[(hydroxyamino)carbonyl]phenyl}ethyl)-1-benzofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) isopropylate / dichloromethane / 6 h / 0 - 20 °C

2.1: dichloromethane; diethyl ether / 20 h / -45 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

4.1: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

4.2: 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

6.1: triethylamine; HATU / dichloromethane / 0.5 h / 20 °C

6.2: 2 h / 20 °C

7.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; triethylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; isopropyl alcohol;