Technology Process of tert-butyl (2S)-2-[(2'R)-2'-hydroxypropyl]pyrrolidine-1-carboxylate
There total 1 articles about tert-butyl (2S)-2-[(2'R)-2'-hydroxypropyl]pyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl pyrrolidine-1-carboxylate;
With
sec.-butyllithium; (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine;
In
diethyl ether; cyclohexane;
at -78 ℃;
for 4h;
Inert atmosphere;
(R)-propylene oxide;
With
boron trifluoride diethyl etherate;
In
diethyl ether; cyclohexane;
at -78 - 0 ℃;
for 3.08333h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/jo4017343
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
1.2: 0 - 20 °C
2.1: dmap; pyridine / dichloromethane / 0 - 20 °C
With
pyridine; dmap; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/acs.jnatprod.0c00871
