{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:256935-71-4
Molecular Formula:C₃₄H₃₂N₂O₇
Molecular Weight:580.637
Hs Code.:

{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9<i>H</i>-fluoren-9-ylmethyl ester

Synonyms:{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of {2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of {2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 3 articles about {2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 256935-70-3
N-(3-(9-fluorenylmethoxycarbonyl)amino-4-methoxybenzoyl)-1-(3,4,5-trimethoxyphenyl)-2-aminoethanol

: 256935-71-4
{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With methoxycarbonylsulfamoyl-triethylammmonium hydroxide; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm010231w

Reference yield:

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: 256935-71-4
{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / 10percent aq. Na₂CO₃ / acetone / 20 °C / pH 8 - 9

2: 84 percent / HATU; N-methylmorpholine / tetrahydrofuran; dimethylformamide / 18 h / 20 °C

3: 97 percent / [(methoxycarbonyl)sulfamoyl]triethylammonium hydroxide / tetrahydrofuran / 2 h / Heating

With 4-methyl-morpholine; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm010231w

Reference yield:

: 256935-69-0
N-Fmoc 3-amino-4-methoxy-benzoic acid

: 256935-71-4
{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-phenyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / HATU; N-methylmorpholine / tetrahydrofuran; dimethylformamide / 18 h / 20 °C

2: 97 percent / [(methoxycarbonyl)sulfamoyl]triethylammonium hydroxide / tetrahydrofuran / 2 h / Heating

With 4-methyl-morpholine; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm010231w