Technology Process of N-(4-benzyloxymethylpyridin-2-yl)-2-(4-fluorophenyl)acetamide
There total 6 articles about N-(4-benzyloxymethylpyridin-2-yl)-2-(4-fluorophenyl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 24h;
DOI:10.1016/j.ejmech.2013.01.014
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / 0 °C / Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C
2.2: 2 h / 0 - 20 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 0 - 20 °C
4.1: p-toluenesulfonyl chloride / dichloromethane / 1.33 h / 0 - 20 °C
5.1: trifluoroacetic acid / dichloromethane / 48 h / Reflux
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C
With
dmap; lithium aluminium tetrahydride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.01.014
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C
1.2: 2 h / 0 - 20 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 0 - 20 °C
3.1: p-toluenesulfonyl chloride / dichloromethane / 1.33 h / 0 - 20 °C
4.1: trifluoroacetic acid / dichloromethane / 48 h / Reflux
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C
With
dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.01.014
