1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

Base Information

Chemical Name:1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane
CAS No.:852336-92-6
Molecular Formula:C₂₀H₃₃ClF₂OSi
Molecular Weight:391.017
Hs Code.:

Synonyms:1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

Suppliers and Price of 1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

Chemical Property:

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Technology Process of 1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

There total 7 articles about 1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 852336-90-4
2-chlorodifluoromethyl-2-isopropyl-4-phenylbutan-1-ol

: 69739-34-0
t-butyldimethylsiyl triflate

: 852336-92-6
1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 27h;
DOI:10.1016/j.jfluchem.2004.11.005

Reference yield:

: 1-chloro-1,1-difluoro-2-phenethyl-2-penten-4-ol

: 852336-92-6
1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / dimethylaminopyridine; Et₃N / CH₂Cl₂ / 2 h / 20 °C

2.1: 81 percent / TMSCl; CuCN / diethyl ether / 0 °C

3.1: O₃ / methanol / 2 h / -78 °C

3.2: 67 percent / NaBH₄ / methanol / 6 h / 0 °C

4.1: 55 percent / dimethylaminopyridine; Et₃N / CH₂Cl₂ / 27 h / 20 °C

With dmap; chloro-trimethyl-silane; ozone; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.jfluchem.2004.11.005

Reference yield:

: 4-chlorodifluoromethyl-4-isopropyl-6-phenyl-2-hexene

: 852336-92-6
1-tert-butyldimethylsilyloxy-2-chlorodifluoromethyl-2-isopropyl-4-phenylbutane

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃ / methanol / 2 h / -78 °C

1.2: 67 percent / NaBH₄ / methanol / 6 h / 0 °C

2.1: 55 percent / dimethylaminopyridine; Et₃N / CH₂Cl₂ / 27 h / 20 °C

With dmap; ozone; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.jfluchem.2004.11.005