tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate

Base Information

Chemical Name:tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate
CAS No.:265129-69-9
Molecular Formula:C₂₆H₄₃NO₂S
Molecular Weight:433.699
Hs Code.:

Synonyms:tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate

Chemical Property:

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Technology Process of tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate

There total 6 articles about tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 60439-16-9
1-bromo-4-cyclohexylbutane

: 247923-33-7
1,1-dimethylethyl 2-[[4-(2-aminoethyl)phenyl]thio]-2-methyl-propanoate

: 265129-69-9
tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2012.08.010

Reference yield:

: 1074-36-8
4-mercaptobenzoic acid

: 265129-69-9
tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 20 °C

2.1: potassium hydroxide / ethanol / 1 h / Reflux

2.2: 1.5 h / Reflux

3.1: triphenylphosphine; hexachloroethane / dichloromethane / 2 h / 20 °C

4.1: dimethyl sulfoxide / 5.5 h / 20 °C

5.1: borane-THF / tetrahydrofuran / 0 °C / Reflux

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With lithium aluminium tetrahydride; borane-THF; hexachloroethane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.010

Reference yield:

: 1402394-03-9
tert-butyl 2-(4-chloromethylphenylthio)-2-methylpropanoate

: 265129-69-9
tert-butyl 2-(4-(2-(N-4-cyclohexylbutyl)aminoethyl)phenylthio)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 5.5 h / 20 °C

2: borane-THF / tetrahydrofuran / 0 °C / Reflux

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With borane-THF; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.010