(S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide

Base Information

• Chemical Name: (S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide
• CAS No.: 119880-81-8
• Molecular Formula: C₃₀H₄₀N₄O₅S
• Molecular Weight: 568.737
• Mol file: 119880-81-8.mol

Synonyms:(S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide

Chemical Property of (S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide

There total 3 articles about (S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-amino-3-methylbutanamide hydrochloride (3014-80-0) + O-tert-butyl-N-dansyltyrosine (119880-76-1) → (S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide (119880-81-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In tetrahydrofuran; butan-1-ol;

DOI:10.1021/ja00187a088

Reference yield:

5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) → (S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide (119880-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaHCO₃ / acetone; H₂O

2: 100 percent / (i-PrN)2C, (i-Pr)2EtN / butan-1-ol; tetrahydrofuran

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In tetrahydrofuran; water; acetone; butan-1-ol;

DOI:10.1021/ja00187a088

Reference yield:

O-t-Butyl-L-tyrosine (4727-00-8,18822-59-8,186698-58-8) → (S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyramide (119880-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaHCO₃ / acetone; H₂O

2: 100 percent / (i-PrN)2C, (i-Pr)2EtN / butan-1-ol; tetrahydrofuran

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In tetrahydrofuran; water; acetone; butan-1-ol;

DOI:10.1021/ja00187a088

upstream raw materials:

(S)-2-amino-3-methylbutanamide hydrochloride

O-tert-butyl-N-dansyltyrosine

5-(dimethylamino)naphth-1-ylsulfonyl chloride

O-t-Butyl-L-tyrosine

Downstream raw materials:

{(S)-2-[(S)-3-(4-tert-Butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyrylamino}-hydroxy-acetic acid

{(S)-2-[(S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-hydroxy-acetic acid