5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

Base Information

Chemical Name:5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate
CAS No.:1258723-87-3
Molecular Formula:C₁₉H₁₆F₃NO₄S
Molecular Weight:411.402
Hs Code.:

Synonyms:5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

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Chemical Property of 5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

There total 5 articles about 5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: C₁₈H₁₇NO₂

: 1258723-87-3
5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/ol102760q

Reference yield:

: C₂₀H₂₂BrNO₃

: 1258723-87-3
5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert-butylmagnesium chloride / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / -78 °C

With tert-butylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol102760q

Reference yield:

: 142-04-1,36663-09-9
aniline hydrochloride

: 1258723-87-3
5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium cyanoborohydride / methanol / 22 h / 20 °C

2.1: dmap / dichloromethane / 60 °C

3.1: tert-butylmagnesium chloride / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / -78 °C

With dmap; tert-butylmagnesium chloride; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol102760q