(+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone

Base Information

Chemical Name:(+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone
CAS No.:144849-35-4
Molecular Formula:C₂₀H₂₂O₅
Molecular Weight:342.392
Hs Code.:

Synonyms:(+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone

Chemical Property:

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Technology Process of (+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone

There total 7 articles about (+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 144849-35-4
(+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone

Guidance literature:: Multi-step reaction with 2 steps

1: HMPA / tetrahydrofuran; hexane / -78 - 20 °C

2: W-2 Raney Ni / ethanol / 2 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; W-2 Raney Ni; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm950387u

Reference yield:

: 836-43-1
4-benzyloxybenzyl alcohol

: 144849-35-4
(+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone

Guidance literature:: Multi-step reaction with 3 steps

1: Ph₃P, Br₂, pyridine / acetonitrile / 0.5 h / 50 °C

2: HMPA / tetrahydrofuran; hexane / -78 - 20 °C

3: W-2 Raney Ni / ethanol / 2 h / Heating

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; bromine; triphenylphosphine; W-2 Raney Ni; In tetrahydrofuran; ethanol; hexane; acetonitrile;
DOI:10.1021/jm950387u

Reference yield:

: 50766-67-1
2-(3,4-dimethoxyphenyl)-1,3-dithiane

: 144849-35-4
(+/-)-trans-2-(4'-hydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 2.5 h

2: HMPA / tetrahydrofuran; hexane / -78 - 20 °C

3: W-2 Raney Ni / ethanol / 2 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; W-2 Raney Ni; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm950387u