N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide
CAS No.:1195778-92-7
Molecular Formula:C₂₈H₂₃FN₄O₄S
Molecular Weight:530.579
Hs Code.:

Synonyms:N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide

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Chemical Property of N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide

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Technology Process of N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide

There total 5 articles about N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345847-75-7
1-(phenylcarbamoyl)cyclopropanecarbonyl chloride

: 1195781-39-5
N-[6-(4-amino-2-fluoro-phenoxy)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide

: 1195778-92-7
N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide

Guidance literature:: In ISOPROPYLAMIDE; at 20 ℃; for 18h;

Reference yield:

: 145591-80-6
1-(phenylcarbamoyl)cyclopropane-1-carboxylic acid

: 1195778-92-7
N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

2: ISOPROPYLAMIDE / 18 h / 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; ISOPROPYLAMIDE;

Reference yield:

: 26278-79-5
2-amino-6-hydroxybenzothiazole

: 1195778-92-7
N-[4-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-3-fluorophenyl]-N'-phenylcyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl acetamide / 0 - 20 °C

2: caesium carbonate / dimethyl sulfoxide / 5 h / 50 °C

3: iron; ammonium chloride / ethanol; water / 4 h / Reflux

4: ISOPROPYLAMIDE / 18 h / 20 °C

With iron; ammonium chloride; caesium carbonate; In ethanol; N,N-dimethyl acetamide; ISOPROPYLAMIDE; water; dimethyl sulfoxide;