Cyclopropanecarboxylic acid, 1-[(phenylamino)carbonyl]-

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 1-[(phenylamino)carbonyl]-
• CAS No.: 145591-80-6
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.213
• Mol file: 145591-80-6.mol

Synonyms:1-(phenylaminocarbonyl)cyclopropanecarboxylic acid;1-phenylcarbamoyl-cyclopropanecarboxylic acid;1-(phenylcarbamoyl)cyclopropanecarboxylic acid;

Chemical Property of Cyclopropanecarboxylic acid, 1-[(phenylamino)carbonyl]-

Chemical Property:

• Boiling Point: 480.3±28.0 °C(Predicted)
• PKA: 3.62±0.20(Predicted)
• PSA: 66.40000
• Density: 1.439±0.06 g/cm3(Predicted)
• LogP: 1.56290
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(phenylcarbamoyl)cyclopropane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-[(phenylamino)carbonyl]-

There total 12 articles about Cyclopropanecarboxylic acid, 1-[(phenylamino)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

ethyl (phenylcarbamoyl)cyclopropanecarboxylate (113117-83-2) → 1-(phenylcarbamoyl)cyclopropane-1-carboxylic acid (145591-80-6)

Guidance literature:

ethyl (phenylcarbamoyl)cyclopropanecarboxylate; With water; potassium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;

Reference yield: 85.0%

methyl 1-(phenylcarbamoyl)cyclopropanecarboxylate (1345847-73-5) → 1-(phenylcarbamoyl)cyclopropane-1-carboxylic acid (145591-80-6)

Guidance literature:

methyl 1-(phenylcarbamoyl)cyclopropanecarboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; pH=4; Cooling with ice;

Reference yield: 68.0%

cyclopropane-1,1-dicarboxylic acid (598-10-7) + aniline (62-53-3) → 1-(phenylcarbamoyl)cyclopropane-1-carboxylic acid (145591-80-6)

Guidance literature:

cyclopropane-1,1-dicarboxylic acid; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With thionyl chloride; In tetrahydrofuran; at 0 ℃; for 0.5h;

aniline; In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1016/j.bmc.2015.09.010

upstream raw materials:

1,1-cyclopropanedicarboxylic acid monoethyl ester

chloroformic acid ethyl ester

1-(chlorocarbonyl)cyclopropane-1-carboxylic acid

aniline

Downstream raw materials:

N-(4-(2-(5-(1,3-dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N'-phenylcyclopropane-1,1-dicarboxamide

tert-butyl 3-(7-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)-thieno[3,2-b]pyridin-2-yl)phenethyl(2-methoxyethyl)carbamate

C₂₉H₂₄FN₅O₃S

cyclopropane-1,1-dicarboxylic acid (3-ethynyl-phenyl)-amide phenylamide

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