6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril

Base Information

Chemical Name:6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril
CAS No.:741628-65-9
Molecular Formula:C₂₄H₂₇N₃O₄
Molecular Weight:421.496
Hs Code.:

Synonyms:6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril

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Chemical Property of 6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril

Chemical Property:

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Technology Process of 6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril

There total 6 articles about 6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61122-82-5
6-chloroacetyl-1,2,3,4-tetrahydroquinolin-2-one

: 741628-65-9
6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 6 steps

1: 2 h / 80 - 90 °C

2: aq. NaOH / 3 h / 60 - 70 °C

3: Et₃N / dimethylformamide / 1 h / Ambient temperature

4: dimethylformamide / 3 h / Ambient temperature

5: 91 percent / H₂ / 10 percent Pd-C / ethanol; H₂O / 45 - 50 °C

6: 1.) NaI; 2.) K₂CO₃ / 1.) DMF, 50-55 deg C, 1 h; 2.) DMF, 70-80 deg C, 4 h

With sodium hydroxide; hydrogen; potassium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.682

Reference yield:

: 70639-77-9
1,2,3,4-tetrahydro-2-oxo-6-quinolinecarboxylic acid

: 741628-65-9
6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dimethylformamide / 1 h / Ambient temperature

2: dimethylformamide / 3 h / Ambient temperature

3: 91 percent / H₂ / 10 percent Pd-C / ethanol; H₂O / 45 - 50 °C

4: 1.) NaI; 2.) K₂CO₃ / 1.) DMF, 50-55 deg C, 1 h; 2.) DMF, 70-80 deg C, 4 h

With hydrogen; potassium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.682

Reference yield:

: C₁₅H₁₇NO₅

: 741628-65-9
6-{4-[2-(4-methoxybenzoyl)ethyl]-1-piperazinylcarbonyl}-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 3 h / Ambient temperature

2: 91 percent / H₂ / 10 percent Pd-C / ethanol; H₂O / 45 - 50 °C

3: 1.) NaI; 2.) K₂CO₃ / 1.) DMF, 50-55 deg C, 1 h; 2.) DMF, 70-80 deg C, 4 h

With hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.682