(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

Base Information

Chemical Name:(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide
CAS No.:888034-62-6
Molecular Formula:C₂₅H₃₉NO₄S
Molecular Weight:449.655
Hs Code.:

Synonyms:(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

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Chemical Property of (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

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Technology Process of (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

There total 1 articles about (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 99295-72-4
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-hydroxybicyclo[2.2.1]heptane-1-methanesulfonamide

: 922-67-8
propynoic acid methyl ester

: 888034-62-6
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

Guidance literature:: With trimethylaluminum; In hexane; toluene; for 72h; Heating;
DOI:10.1021/jo0602569

Reference yield: 56.0%

: 888034-62-6
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

: 2904-57-6
mesitylenecarbonitrile oxide

: 888034-68-2
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

: (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(3-(2,4,6-trimethylphenyl)isoxazole-5-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

Guidance literature:: In tetrahydrofuran; for 168h; Heating;
DOI:10.1021/jo0602569

Reference yield:

: 888034-62-6
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-propynoyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

: (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-((4S,5S)-5-tert-butyl-3-(2,4,6-trimethylphenyl)-Δ²-isoxazoline-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 19 percent / tetrahydrofuran / 168 h / Heating

2: 87 percent / zinc; cuprous iodide / aq. methanol / 312 h / 5 °C / sonication

With copper(l) iodide; zinc; In tetrahydrofuran; methanol;
DOI:10.1021/jo0602569