Technology Process of 2-(2-(4-methoxybenzoyl)pent-4-en-1-yl)isoindoline-1,3-dione
There total 3 articles about 2-(2-(4-methoxybenzoyl)pent-4-en-1-yl)isoindoline-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(3-(4-methoxyphenyl)prop-2-yn-1-yl)isoindoline-1,3-dione; allyl alcohol;
With
silver tetrafluoroborate; [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride;
In
tetrahydrofuran;
at 65 ℃;
for 15h;
Inert atmosphere;
In
tetrahydrofuran;
at 120 ℃;
for 6h;
diastereoselective reaction;
Sealed tube;
DOI:10.1039/c2cc37166a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere
2.1: [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; silver tetrafluoroborate / tetrahydrofuran / 15 h / 65 °C / Inert atmosphere
2.2: 6 h / 120 °C / Sealed tube
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver tetrafluoroborate; [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; triethylamine;
In
tetrahydrofuran; acetonitrile;
1.1: |Sonogashira Cross-Coupling / 2.2: |Claisen Rearrangement;
DOI:10.1039/c2cc37166a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere
2.1: [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; silver tetrafluoroborate / tetrahydrofuran / 15 h / 65 °C / Inert atmosphere
2.2: 6 h / 120 °C / Sealed tube
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver tetrafluoroborate; [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; triethylamine;
In
tetrahydrofuran; acetonitrile;
1.1: |Sonogashira Cross-Coupling / 2.2: |Claisen Rearrangement;
DOI:10.1039/c2cc37166a
