N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester

Base Information

• Chemical Name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester
• CAS No.: 327187-74-6
• Molecular Formula: C₃₂H₄₁N₃O₆
• Molecular Weight: 563.694
• Mol file: 327187-74-6.mol

Synonyms:N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester

Chemical Property of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester

There total 1 articles about N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[Methyl-((S)-pyrrolidine-2-carbonyl)-amino]-acetic acid tert-butyl ester (63219-23-8) + N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) → N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester (327187-74-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(00)00963-7

Reference yield:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-valyl-prolyl-sarcosine tert-butyl ester (327187-74-6) → O-[N-benzyloxycarbonyl-N-methylvalyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-threonyl-D-valyl-prolyl-sarcosine tert-butyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: Et₂NH / acetonitrile / 0.5 h

2: 0.446 g / CMBI; DIEA / CH₂Cl₂ / 1 h / 20 °C

3: 89.3 percent / CMBI; DIEA; DMAP / CH₂Cl₂ / 4 h / 20 °C

With dmap; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; 1: deacylation / 2: Acylation / 3: Esterification;

DOI:10.1016/S0040-4020(00)00963-7

upstream raw materials:

[Methyl-((S)-pyrrolidine-2-carbonyl)-amino]-acetic acid tert-butyl ester

N-(9-fluorenylmethoxycarbonyl)-D-valine