Technology Process of (E)-3-(3-fluorophenyl)-2-methylacrylaldehyde
There total 3 articles about (E)-3-(3-fluorophenyl)-2-methylacrylaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 18h;
Inert atmosphere;
DOI:10.1002/adsc.202000831
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2: Dess-Martin periodane / dichloromethane / 18 h / 20 °C / Inert atmosphere
With
diisobutylaluminium hydride; Dess-Martin periodane;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/adsc.202000831
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere
1.2: 24 h / 0 - 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
3.1: Dess-Martin periodane / dichloromethane / 18 h / 20 °C / Inert atmosphere
With
sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane;
In
tetrahydrofuran; hexane; dichloromethane; mineral oil;
DOI:10.1002/adsc.202000831
