(E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide

Base Information

• Chemical Name: (E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide
• CAS No.: 1375800-56-8
• Molecular Formula: C₂₇H₃₅FN₂O₄
• Molecular Weight: 470.584
• Mol file: 1375800-56-8.mol

Synonyms:(E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide

Chemical Property of (E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide

There total 4 articles about (E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(E)-3-(3-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine (1375800-68-2) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → (E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide (1375800-56-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.02.041

Reference yield:

Eudesmic acid (118-41-2) → (E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide (1375800-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / Reflux

2: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2012.02.041

Reference yield:

3-Fluorobenzaldehyde (456-48-4) → (E)-N-(3-(3-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide (1375800-56-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 0 - 20 °C / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 120 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

3.2: 0.17 h / 20 °C

3.3: pH > 10

4.1: triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; magnesium sulfate; triethylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2012.02.041

upstream raw materials:

(E)-3-(3-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

3,4,5-Trimethoxybenzoyl chloride

(E)-3-(3-fluorophenyl)-2-methylacrylaldehyde

Eudesmic acid