methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate

Base Information

Chemical Name:methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate
CAS No.:1560987-56-5
Molecular Formula:C₂₀H₁₇FN₄O₂S₂
Molecular Weight:428.511
Hs Code.:

Synonyms:methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate

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Chemical Property of methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate

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Technology Process of methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate

There total 3 articles about methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 4897-84-1
Methyl 4-bromobutyrate

: 1560987-51-0
3-[2'-fluoro-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-6-thiol

: 1560987-56-5
methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.0833333h; Temperature; Microwave irradiation;
DOI:10.1007/s00044-014-0944-x

Reference yield:

: 1560987-48-5
4-amino-5-[2'-fluoro-(1,1'-biphenyl)-3-yl]-4H-1,2,4-triazole-3-thiol

: 1560987-56-5
methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 4 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 50 °C / Microwave irradiation

With potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/s00044-014-0944-x

Reference yield:

: 1253043-54-7
C₁₄H₉FN₂OS

: 1560987-56-5
methyl 4-{[3-(2'-fluoro-(1,1'-biphenyl)-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]sulfanyl}butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 6 h / Reflux

2: potassium hydroxide / ethanol / 4 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 50 °C / Microwave irradiation

With hydrazine hydrate; potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/s00044-014-0944-x