(1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol

Base Information

Chemical Name:(1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol
CAS No.:180633-70-9
Molecular Formula:C₂₄H₂₈IN₃O₄SSi
Molecular Weight:609.56
Hs Code.:

Synonyms:(1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol

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Chemical Property of (1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol

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Technology Process of (1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol

There total 1 articles about (1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 80360-14-1
3-iodo-1-phenylsulfonyl-1H-indole

: 180633-57-2
4-iodo-[2-(trimethylsilyl)ethoxy]methyl-1H-imidazole-2-carboxaldehyde

: 180633-70-9
(1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol

Guidance literature:: 3-iodo-1-phenylsulfonyl-1H-indole; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -90 ℃; for 0.0833333h;

4-iodo-[2-(trimethylsilyl)ethoxy]methyl-1H-imidazole-2-carboxaldehyde; In tetrahydrofuran; pentane; at -90 - -20 ℃; for 2h; Further stages.;
DOI:10.1016/j.tet.2008.04.045

Reference yield: 93.0%

: 180633-70-9
(1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol

: 180633-72-1
(1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanone

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2008.04.045

Reference yield:

: 180633-70-9
(1-benzenesulfonyl-1H-indol-3-yl)-[4-iodo-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-imidazol-2-yl]-methanol

: 1038921-27-5
[4-(1-benzenesulfonyl-6-bromo-1H-indol-3-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-(1-benzenesulfonyl-1H-indol-3-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / MnO₂ / CH₂Cl₂ / 4 h / Ambient temperature

2: 74 percent / CuI / PdCl₂(PPh₃)2 / dimethylformamide / 2 h / 120 °C

With manganese(IV) oxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)01148-3