(E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione

Base Information

• Chemical Name: (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione
• CAS No.: 1397643-49-0
• Molecular Formula: C₁₉H₁₆N₆OS
• Molecular Weight: 376.442

Synonyms:(E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione

Chemical Property of (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione

Chemical Property:

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Technology Process of (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione

There total 2 articles about (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-amino-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione (1397643-35-4) + 4-methyl-benzaldehyde (104-87-0) → (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione (1397643-49-0)

Guidance literature:

With sulfuric acid; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.2174/157018012801319526

Reference yield:

3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoic acid (23464-98-4) → (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione (1397643-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 h / Heating; Neat (no solvent)

2: sulfuric acid / N,N-dimethyl-formamide / 5 h / 20 °C

With sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.2174/157018012801319526

Reference yield: 86.0%

Thiomorpholin (123-90-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione (1397643-49-0) → (E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1-(thiomorpholinomethyl)-1H-1,2,4-triazole-5(4H)-thione (1397643-92-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.2174/157018012801319526

upstream raw materials:

4-amino-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1H-1,2,4-triazole-5(4H)-thione

4-methyl-benzaldehyde

3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoic acid

Downstream raw materials:

(E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1-(piperidin-1-ylmethyl)-1H-1,2,4-triazole-5(4H)-thione

(E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1-(morpholinomethyl)-1H-1,2,4-triazole-5(4H)-thione

(E)-4-(4-methylbenzylideneamino)-3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-1-(thiomorpholinomethyl)-1H-1,2,4-triazole-5(4H)-thione

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