3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester

Base Information

• Chemical Name: 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester
• CAS No.: 1038923-37-3
• Molecular Formula: C₂₉H₂₆N₂O₃
• Molecular Weight: 450.537

Synonyms:3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester

Chemical Property of 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester

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Technology Process of 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester

There total 1 articles about 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

3-(4-bromo-phenyl)-2-pyridin-3-yl-propionic acid ethyl ester (501031-48-7) + 5-methyl-2-phenyl-4-(2-propynyl)oxazole (140130-10-5) → 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester (1038923-37-3)

Guidance literature:

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 20h;

DOI:10.1016/j.bmc.2008.03.043

Reference yield: 82.0%

3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester (1038923-37-3) → 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester (501031-85-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 16h;

DOI:10.1016/j.bmc.2008.03.043

Reference yield: 37.0%

3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester (1038923-37-3) → 3-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]-phenyl}-2-pyridin-3-yl-propionic acid (501029-33-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2008.03.043

upstream raw materials:

3-(4-bromo-phenyl)-2-pyridin-3-yl-propionic acid ethyl ester

5-methyl-2-phenyl-4-(2-propynyl)oxazole

Downstream raw materials:

3-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-prop-1-ynyl]-phenyl}-2-pyridin-3-yl-propionic acid

3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]phenyl}-2-pyridin-3-yl-propionic acid ethyl ester

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